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Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per Chem/Drugbox validation
Importing Wikidata short description: "Chemical compound"
 
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{{Short description|Chemical compound}}
{{drugbox
{{Drugbox
| Watchedfields = changed
⚫
| verifiedrevid =
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| IUPAC_name = 5-[()methyl]-3-{[(1''E'')-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
⚫
| image = Nifuratel.
| width = 275

<!--Clinical data-->
| tradename =
| Drugs.com = {{drugs.com|international|nifuratel}}
⚫
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| pregnancy_US = <!-- A / B / C / D / X -->
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| pregnancy_category=
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
⚫
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
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| legal_status
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| routes_of_administration =

<!--Pharmacokinetic data-->
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| bioavailability
| protein_bound =
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| metabolism
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| elimination_half-life =
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| excretion =

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
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| CAS_number = 4936-47-4
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| ATC_prefix = G01
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| ATC_suffix = AX05
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| PubChem = 6433427
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
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| DrugBank
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = U60U6P08SP
| UNII = U60U6P08SP
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| verifiedrevid = 443795193
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| IUPAC_name = 5-[(methylthio)methyl]-3-{[(1''E'')-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
⚫
| image = Nifuratel.png
⚫
| CAS_number = 4936-47-4
⚫
| ATC_prefix = G01
⚫
| ATC_suffix = AX05
⚫
| PubChem = 6433427
⚫
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
⚫
| DrugBank =
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D01050
| KEGG = D01050
| ChemSpiderID = 4938579
| C=10|H=11|N=3|O=5|S=1

| molecular_weight = 285.28 g/mol
<!--Chemical data-->
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| bioavailability =
| protein_bound =
| =
| smiles = CSCC1CN(C(=O)O1)/N=C/C2=CC=C(O2)[N+](=O)[O-]
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| metabolism =
| StdInChI = 1S/C10H11N3O5S/c1-19-6-8-5-12(10(14)18-8)11-4-7-2-3-9(17-7)13(15)16/h2-4,8H,5-6H2,1H3/b11-4+
⚫
| elimination_half-life =
| StdInChIKey = SRQKTCXJCCHINN-NYYWCZLTSA-N
⚫
| excretion =

⚫
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫
| pregnancy_US = <!-- A / B / C / D / X -->
⚫
| pregnancy_category=
⚫
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
⚫
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
⚫
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫
| legal_status =
⚫
| routes_of_administration =
}}
}}


'''Nifuratel''' is a drug used in [[gynecology]]. It is a local antiprotozoal and antifungal agent that may also be given orally.
'''Nifuratel''' is a drug used in [[gynecology]]. It is a local antiprotozoal and antifungal agent that may also be given orally.


Nifuratel appears to have a broad antibacterial spectrum of action and is effective against ''Chlamydia trachomatis'' and ''Mycoplasma spp.'' as well as fungal infections from ''Candida spp.''<ref> Treatment of candidal urinary tract infection with nifuratel. R N Grüneberg, A Leakey </ref>
Nifuratel appears to have a broad antibacterial spectrum of action and is effective against ''Chlamydia trachomatis'' and ''Mycoplasma spp.'' as well as fungal infections from ''Candida spp.''<ref> Treatment of candidal urinary tract infection with nifuratel </ref>


Taken orally, or as a vaginal pessary, it is used in the treatment of a wide range of infections of the genito-urinary tract, especially if there is no accurate diagnosis available. For example it may be used in the treatment of women exhibiting vaginal discharge where there is uncertainty as to whether the cause is ''Trichomonas vaginalis'' or ''Candida'' strains such as ''Candida albicans''.
Taken orally, or as a vaginal pessary, it is used in the treatment of a wide range of infections of the genito-urinary tract, especially if there is no accurate diagnosis available. For example it may be used in the treatment of women exhibiting vaginal discharge where there is uncertainty as to whether the cause is ''Trichomonas vaginalis'' or ''Candida'' strains such as ''Candida albicans''.


Side effects appear to be minimal or non-existent and it has a safe toxicological profile.<ref> Microbiological and pharmaco-toxicological profile of nifuratel and its favourable risk/benefit ratio for the treatment of vulvo-vaginal infections. A review. Werner Mendling, Federico Mailland
Side effects appear to be minimal or non-existent and it has a safe toxicological profile.<ref> Microbiological and pharmaco-toxicological profile of nifuratel and its favourable risk/benefit ratio for the treatment of vulvo-vaginal infections. A review
Klinik für Frauenheilkunde und Geburtshilfe, Klinikum Am Urban, Berlin, Germany. </ref>


==References==
==References==
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[[Category:Thioethers]]
[[Category:Thioethers]]
[[Category:Oxazolidinones]]
[[Category:Oxazolidinones]]
[[Category:Nitrofurans]]
[[Category:Nitrofurans]]

[[it:Nifuratel]]
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