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Psychotridine

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Psychotridine
Clinical data
ATC code
  • none
Identifiers
  • 3-methyl-5,8b-bis[3-methyl-5-(3-methyl-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl)-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-8b-yl]-1,2,3a,4-tetrahydropyrrolo[2,3-b]indole
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC55H62N10
Molar mass863.171 g·mol−1
3D model (JSmol)
  • CN1CCC2(C1NC1=CC=CC=C21)C1=CC=CC2=C1NC1N(C)CCC21C1=CC=CC2=C1NC1N(C)CCC21C12CCN(C)C1NC1=C2C=CC=C1C12CCN(C)C1NC1=CC=CC=C21

Psychotridine is an alkaloid found in some species of the genus Psychotria, namely Psychotria colorata,[1] but also Psychotria forsteriana,[2] Psychotria lyciiflora,[3] Psychotria oleoides,[3] and Psychotria beccarioides.[4] Psychotridine has analgesic effects and dose-dependently inhibits dizocilpine binding to cortical membranes in vitro, suggesting that it acts as a non-competitive NMDA receptor antagonist.[1]

See also

[edit]

References

[edit]
  1. ^ a b Amador TA, Verotta L, Nunes DS, Elisabetsky E (May 2001). "Involvement of NMDA receptors in the analgesic properties of psychotridine". Phytomedicine. 8 (3): 202–206. doi:10.1078/0944-7113-00025. PMID 11417913.
  2. ^ Beretz A, Roth-Georger A, Corre G, Kuballa B, Anton R, Cazenave JP (August 1985). "Polyindolinic Alkaloids from Psychotria forsteriana. Potent Inhibitors of the Aggregation of Human Platelets". Planta Medica. 51 (4): 300–303. doi:10.1055/s-2007-969496. PMID 17340518. S2CID 12146923.
  3. ^ a b Jannic V, Guéritte F, Laprévote O, Serani L, Martin MT, Sévenet T, Potier P (June 1999). "Pyrrolidinoindoline alkaloids from Psychotria oleoides and Psychotria lyciiflora". Journal of Natural Products. 62 (6): 838–843. doi:10.1021/np9805387. PMID 10395499.
  4. ^ Hart N, Johns S, Lamberton J, Summons R (1974). "Psychotridine, a C55H62N10 alkaloid from Psychotria beccarioides (Rubiaceae)". Australian Journal of Chemistry. 27 (3): 639–646. doi:10.1071/ch9740639.


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