LY9

LY9
Identifiers
Aliases	LY9, CD229, SLAMF3, hly9, mlymphocyte antigen 9
External IDs	OMIM: 600684; MGI: 96885; HomoloGene: 1759; GeneCards: LY9; OMA:LY9 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,828,261 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,434,978 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; buccal mucosa cell; ; blood; ; spleen; ; bone marrow cells; ; epithelium of colon; ; superficial temporal artery; ; appendix; ; trabecular bone;
	Top expressed in
	mesenteric lymph nodes; ; stroma of bone marrow; ; thymus; ; spleen; ; granulocyte; ; blood; ; subcutaneous adipose tissue; ; calvaria; ; white adipose tissue; ; right lung lobe;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	integral component of membrane; cell surface; plasma membrane; membrane;
Biological process	positive regulation of interleukin-17 production; innate immune response; cell adhesion; adaptive immune response; T-helper 17 cell lineage commitment; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	4063
	17085
	ENSG00000122224
	ENSMUSG00000004707
	Q9HBG7; Q5VYI1
	Q01965
	NM_001033667; NM_001261456; NM_001261457; NM_002348
	NM_001277968; NM_008534
	NP_001028839; NP_001248385; NP_001248386; NP_002339
	NP_001264897; NP_032560
	Wikidata
View/Edit Human	View/Edit Mouse

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene.^[5]^[6]^[7] LY9 has also recently been designated CD229 (cluster of differentiation 229).

Interactions

LY9 has been shown to interact with SH2D1A.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122224 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004707 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF (Feb 1996). "Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9". Immunogenetics. 43 (1–2): 13–9. doi:10.1007/bf00186599. PMID 8537117. S2CID 10045488.
^ Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (Aug 1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics. 42 (1): 59–62. doi:10.1007/BF00164988. PMID 7797269. S2CID 28529549.
^ "Entrez Gene: LY9 lymphocyte antigen 9".
^ Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–3874. doi:10.1182/blood.V97.12.3867. PMID 11389028.
^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). J. Biol. Chem. 276 (39): 36809–36816. doi:10.1074/jbc.M101305200. PMID 11477068. S2CID 39889619.

External links

LY9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122224 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004707 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8537117-5] Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF (Feb 1996). "Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9". Immunogenetics. 43 (1–2): 13–9. doi:10.1007/bf00186599. PMID 8537117. S2CID 10045488.

[pmid7797269-6] Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (Aug 1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics. 42 (1): 59–62. doi:10.1007/BF00164988. PMID 7797269. S2CID 28529549.

[entrez-7] "Entrez Gene: LY9 lymphocyte antigen 9".

[pmid11389028-8] Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–3874. doi:10.1182/blood.V97.12.3867. PMID 11389028.

[pmid11477068-9] Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). J. Biol. Chem. 276 (39): 36809–36816. doi:10.1074/jbc.M101305200. PMID 11477068. S2CID 39889619.

[5]

LY9

Contents

Interactions

References

Further reading

External links