Abstract
Pharmacodynamics is the study of the time course of pharmacological effects of drugs. The field of pharmacodynamic modeling has made many advances, due in part to the relatively recent development of basic and extended mechanism-based models. The purpose of this article is to describe the classic as well as contemporary approaches, with an emphasis on pertinent equations and salient model features. In addition, current methods of integrating various system complexities into these models are discussed. Future pharmacodynamic models will most likely reflect an assembly of the basic components outlined in this review.
Footnotes
-
↵1 Current address: Gerontology Research Center, 5600 Nathan Shock Dr., Baltimore, MD 21224.
-
↵2 Current address: Department of Pharmacokinetics and Physical Pharmacy, Jagiellonian University, 9 Medyczna St., 30-688 Krakow, Poland.
-
This work was supported by Grant GM57980 from the National Institutes of General Medicine (National Institutes of Health) and a Predoctoral Fellowship to D.E.M. from the American Foundation for Pharmaceutical Education.
- Abbreviations used are::
- PD
- pharmacodynamics
- PK
- pharmacokinetics
- TAT
- tyrosine aminotransferase
- Received September 26, 2002.
- Accepted February 3, 2003.
- The American Society for Pharmacology and Experimental Therapeutics
DMD articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|