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Prognostic Significance of High Phosphatase of Regenerating Liver-3 Expression in Patients with Gastric Cancer Who Underwent Curative Gastrectomy

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Abstract

Background

Although a close correlation between PRL-3 overexpression and lymph node metastasis has been reported in gastric cancer, its clinical utility as a useful prognostic molecular marker remains unclear.

Methods

Prognostic significance of PRL-3 expression was analyzed immunohistochemically in 110 patients with gastric cancer who had undergone curative gastrectomy.

Results

There was a significant correlation between gender, histology, lymph node metastasis, the presence of recurrence, and the level of PRL-3 expression. Recurrence in patients with high PRL-3 expression was significantly higher than that for patients with low PRL-3 expression (p < 0.001). The median overall survival (OS) time and 2-year OS rate for patients with high or moderate PRL-3 expressed tumors were worse than those of patients with low PRL-3 expressed tumor (p = 0.001). In addition, patients with low PRL-3 expression had a higher DFS rate and the median DFS interval than those of moderate or high PRL-3 expressed patients (p < 0.001). Multivariate analysis indicated that the rate of PRL-3 expression was an independent prognostic factor, in addition to the already-known important clinicopathological prognostic indicator for both DFS and OS.

Conclusions

The potential value of PRL-3 expression as a useful molecular marker in gastric cancer progression should be evaluated comprehensively; it may predict recurrence and poor prognosis in patients with gastric cancer after curative resection.

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Authors and Affiliations

  1. Department of Medical Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey

    Ahmet Bilici, Bala Basak Oven Ustaalioglu, Mesut Seker & Mahmut Gumus

  2. Department of Pathology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey

    Dilek Yavuzer

  3. Department of Radiation Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey

    Alpaslan Mayadagli

  4. Menderes Mah, 364.Sok., Caglar Apt, No: 16, Daire: 1, 34210, Esenler, Istanbul, Turkey

    Ahmet Bilici

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  1. Ahmet Bilici
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  2. Bala Basak Oven Ustaalioglu
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Correspondence to Ahmet Bilici.

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Bilici, A., Ustaalioglu, B.B.O., Yavuzer, D. et al. Prognostic Significance of High Phosphatase of Regenerating Liver-3 Expression in Patients with Gastric Cancer Who Underwent Curative Gastrectomy. Dig Dis Sci 57, 1568–1575 (2012). https://doi.org/10.1007/s10620-012-2076-9

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  • DOI: https://doi.org/10.1007/s10620-012-2076-9

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