Abstract
Rapidly adapting (RA) currents expressed in dorsal root ganglia somatosensory neurons reduce their amplitude in response to prolonged and/or repeated mechanical stimulation. Both inactivation of mechanotransducer channels and adaptation of the force acting on the channels have been suggested to independently decrease RA currents. However, these two mechanisms have similar kinetics and dependence on calcium and voltage. These experimental findings suggest that a single mechanism might underlie both. We constructed a simple Hodgkin–Huxley-type model with a single gating variable driving both inactivation and adaptation to test this hypothesis. Predictions of the model successfully describe key features of mechanical activation as well as inactivation, adaptation, and recovery. The model thus supports the possibility of a single mechanism driving inactivation and adaptation in RA currents. On its own, the model can be integrated into higher-order models of touch receptors because of its accurate simulation of RA currents.
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Acknowledgments
We are grateful to Drs Patrick Delmas and Jizhé Hao for sending us some of the experimental data and to Eric James McDermott for proofreading.
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TR was supported by EU FP7 NanoBioTouch. JB was supported by BMBF Bernstein Award Computational Neuroscience 01GQ0802. JP received support from the Slovenian Research Agency, project ARRS-Z3-4061, and AŠ received support from the Slovenian Research Agency, project ARRS-Z1-4288.
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Prešern, J., Škorjanc, A., Rodič, T. et al. A single mechanism driving both inactivation and adaptation in rapidly adapting currents of DRG neurons?. Biol Cybern 110, 393–401 (2016). https://doi.org/10.1007/s00422-016-0693-7
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DOI: https://doi.org/10.1007/s00422-016-0693-7