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Structure-Specific Statistical Mapping of White Matter Tracts

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Visualization and Processing of Tensor Fields

Part of the book series: Mathematics and Visualization ((MATHVISUAL))

Summary

We present a new model-based framework for the statistical analysis of diffusion imaging data associated with specific white matter tracts. The framework takes advantage of the fact that several of the major white matter tracts are thin sheet-like structures that can be effectively modeled by medial representations. The approach involves segmenting major tracts and fitting them with deformable geometric medial models. The medial representation makes it possible to average and combine tensor-based features along directions locally perpendicular to the tracts, thus reducing data dimensionality and accounting for errors in normalization. The framework enables the analysis of individual white matter structures, and provides a range of possibilities for computing statistics and visualizing differences between cohorts. The framework is demonstrated in a study of white matter differences in pediatric chromosome 22q11.2 deletion syndrome.

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Acknowledgments

This work was supported by the NIH grants AG027785 (PY), NS061111 (PY), HD042974 (TJC), HD046159 (TJC), MH068066 (V. Megalooikonomou), and NS045839 (J.A. Detre).

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Authors and Affiliations

  1. Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA

    Paul A. Yushkevich & James C. Gee

  2. Department of Psychiatry and Behavioral Sciences, M.I.N.D. Institute, University of California, Davis, CA, USA

    Hui Zhang & Tony J. Simon

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  1. Paul A. Yushkevich
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  4. James C. Gee
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Editors and Affiliations

  1. Department of Computer Science, Brown University, Box 1910, 02912, Providence, RI, USA

    David Laidlaw

  2. Faculty of Mathematics and Computer Science Mathematical Image Analysis Group, Saarland University, 66041, Saarbrücken, Germany

    Joachim Weickert

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Yushkevich, P.A., Zhang, H., Simon, T.J., Gee, J.C. (2009). Structure-Specific Statistical Mapping of White Matter Tracts. In: Laidlaw, D., Weickert, J. (eds) Visualization and Processing of Tensor Fields. Mathematics and Visualization. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88378-4_5

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