MBOAT7
Lizofosfolipid-aciltransferaza 7, znana i kao membranski vezani O-aciltransferazni domen-sadržavajući protein 7 (MBOAT7) je enzim koji je kod ljudi kodiran genom MBOAT7.[5] To je homolog ostalih membranski vezanih O-aciltransferaza.
Aminokiselinska sekvenca
uredi| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MSPEEWTYLV | VLLISIPIGF | LFKKAGPGLK | RWGAAAVGLG | LTLFTCGPHT | ||||
| LHSLVTILGT | WALIQAQPCS | CHALALAWTF | SYLLFFRALS | LLGLPTPTPF | ||||
| TNAVQLLLTL | KLVSLASEVQ | DLHLAQRKEM | ASGFSKGPTL | GLLPDVPSLM | ||||
| ETLSYSYCYV | GIMTGPFFRY | RTYLDWLEQP | FPGAVPSLRP | LLRRAWPAPL | ||||
| FGLLFLLSSH | LFPLEAVRED | AFYARPLPAR | LFYMIPVFFA | FRMRFYVAWI | ||||
| AAECGCIAAG | FGAYPVAAKA | RAGGGPTLQC | PPPSSPEKAA | SLEYDYETIR | ||||
| NIDCYSTDFC | VRVRDGMRYW | NMTVQWWLAQ | YIYKSAPARS | YVLRSAWTML | ||||
| LSAYWHGLHP | GYYLSFLTIP | LCLAAEGRLE | SALRGRLSPG | GQKAWDWVHW | ||||
| FLKMRAYDYM | CMGFVLLSLA | DTLRYWASIY | FCIHFLALAA | LGLGLALGGG | ||||
| SPSRRKAASQ | PTSLAPEKLR | EE |
- Simboli
Funkcija
urediOvaj gen kodira člana membranski vezanog O-transferazne porodice integralnih membranskih proteina koji imaju aktivnost atiltransferaze. Kodirani protein je lizofosfolipid-aciltransferaza koja ima specifičnost za arahidonoil-CoA kao acil donora. Ovaj protein je uključen u reacilaciju fosforipida, kao dio puta za preuređenje fosforipida poznat kao kopneni ciklus.[5]
Reference
uredi- ^ a b c ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 GRCh38: Ensembl release 89: ENSG00000273592, ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035596 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Membrane bound O-acyltransferase domain containing 7".
Dopunska literatura
uredi- Wende H, Volz A, Ziegler A (juli 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
- Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H (mart 2008). "Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol". Mol. Biol. Cell. 19 (3): 1174–84. doi:10.1091/mbc.E07-09-0893. PMC 2262980. PMID 18094042.
- Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T (april 2009). "Recent progress on acyl CoA: lysophospholipid acyltransferase research". J. Lipid Res. 50 Suppl: S46–51. doi:10.1194/jlr.R800035-JLR200. PMC 2674719. PMID 18931347.
- Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR (oktobar 2008). "Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils". J. Biol. Chem. 283 (44): 30235–45. doi:10.1074/jbc.M806194200. PMC 2573059. PMID 18772128.
- Fukunaga-Johnson N, Lee SW, Liebert M, Grossman HB (1996). "Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma". Anticancer Res. 16 (3A): 1085–90. PMID 8702217.