Phosphotransferase: Difference between revisions
RetroS1mone (talk | contribs) →Phosphostransferase system: i link PTS |
Shiningheart (talk | contribs) Added classification of phosphotransferases category and citations. |
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A—''P'' + B ⇔ B—''P'' + A |
A—''P'' + B ⇔ B—''P'' + A |
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Where ''P'' is a [[phosphate group]] and A and B are the donating and accepting molecules, respectively. |
Where ''P'' is a [[phosphate group]] and A and B are the donating and accepting molecules, respectively. |
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== Classification of Phosphotransferases == |
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==Phosphostransferase system== |
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Phosphotransferases are generally classified according to the acceptor molecule<ref>[http://science.jrank.org/pages/38986/phosphotransferase.html] Phosphotransferases are any enzyme of sub‐subclasses EC 2.7.1 to 2.7.4, and EC 2.7.9</ref><ref>[http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/7/], Classification in this article follows the rules of Enzyme Nomenclature of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB).</ref>. |
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*EC 2.7.1 Phosphotransferases with an [[alcohol]] group as acceptor |
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*EC 2.7.2 Phosphotransferases with a [[carboxy]] group as acceptor |
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*EC 2.7.3 Phosphotransferases with a nitrogenous group as acceptor |
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*EC 2.7.4 Phosphotransferases with a [[phosphate]] group as acceptor |
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*EC 2.7.9 Phosphotransferases with paired acceptors. In these reactions, a single [[nucleotide|triphophate-nucleotide]] transfers two phosphates to two different acceptor molecules, resulting in a monophosphate-nucleotide and two phosphorylated products. |
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== Phosphotransferase system == |
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The [[PEP group translocation|phosphotransferase system]] (PTS) is a complex group translocation system present in many bacteria. The PTS transports sugars (such as [[glucose]], [[mannose]], and [[mannitol]]) into the cell. The first step of this reaction is phosphorylation of the substrate via phosphotransferase during transport. In the case of glucose, the product of this phosphorylation is Glucose-6-Phosphate (Glu-6P). |
The [[PEP group translocation|phosphotransferase system]] (PTS) is a complex group translocation system present in many bacteria. The PTS transports sugars (such as [[glucose]], [[mannose]], and [[mannitol]]) into the cell. The first step of this reaction is phosphorylation of the substrate via phosphotransferase during transport. In the case of glucose, the product of this phosphorylation is Glucose-6-Phosphate (Glu-6P). |
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Due to the negative charge of the phosphate, this Glu-6P can no longer freely leave the cell. This is the first reaction of [[glycolysis]], which degrades the sugar to [[pyruvate]]. |
Due to the negative charge of the phosphate, this Glu-6P can no longer freely leave the cell. This is the first reaction of [[glycolysis]], which degrades the sugar to [[pyruvate]]. |
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== |
== == |
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* [[Kinase]] |
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* [[Diphosphotransferase]] |
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== References == |
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<references/> |
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== External links == |
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* {{MeshName|Phosphotransferases}} |
* {{MeshName|Phosphotransferases}} |
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Revision as of 23:19, 20 December 2009
Phosphotransferases are a category of enzymes (EC number 2.7) which catalyze phosphorylation reactions. The general form of the reactions they catalyze is:
A—P + B ⇔ B—P + A
Where P is a phosphate group and A and B are the donating and accepting molecules, respectively.
Classification of Phosphotransferases
Phosphotransferases are generally classified according to the acceptor molecule[1][2].
- EC 2.7.1 Phosphotransferases with an alcohol group as acceptor
- EC 2.7.2 Phosphotransferases with a carboxy group as acceptor
- EC 2.7.3 Phosphotransferases with a nitrogenous group as acceptor
- EC 2.7.4 Phosphotransferases with a phosphate group as acceptor
- EC 2.7.9 Phosphotransferases with paired acceptors. In these reactions, a single triphophate-nucleotide transfers two phosphates to two different acceptor molecules, resulting in a monophosphate-nucleotide and two phosphorylated products.
Phosphotransferase system
The phosphotransferase system (PTS) is a complex group translocation system present in many bacteria. The PTS transports sugars (such as glucose, mannose, and mannitol) into the cell. The first step of this reaction is phosphorylation of the substrate via phosphotransferase during transport. In the case of glucose, the product of this phosphorylation is Glucose-6-Phosphate (Glu-6P). Due to the negative charge of the phosphate, this Glu-6P can no longer freely leave the cell. This is the first reaction of glycolysis, which degrades the sugar to pyruvate.
See Also
References
External links
- Phosphotransferases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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