Review
doi: 10.1038/nrm1835.
Complex networks orchestrate epithelial-mesenchymal transitions
Affiliations
- PMID: 16493418
- DOI: 10.1038/nrm1835
Item in Clipboard
Review
Complex networks orchestrate epithelial-mesenchymal transitions
Nat Rev Mol Cell Biol.
2006 Feb.
Abstract
Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Similar articles
-
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.Dev Cell. 2008 Jun;14(6):818-29. doi: 10.1016/j.devcel.2008.05.009. Dev Cell. 2008. PMID: 18539112 Review.
-
Epithelial type, ingression, blastopore architecture and the evolution of chordate mesoderm morphogenesis.J Exp Zool B Mol Dev Evol. 2008 Jan 15;310(1):85-110. doi: 10.1002/jez.b.21198. J Exp Zool B Mol Dev Evol. 2008. PMID: 18041055 Review.
-
A human three-dimensional cell line model allows the study of dynamic and reversible epithelial-mesenchymal and mesenchymal-epithelial transition that underpins colorectal carcinogenesis.Cells Tissues Organs. 2007;185(1-3):20-8. doi: 10.1159/000101299. Cells Tissues Organs. 2007. PMID: 17587804 Review.
-
Signal transduction pathways involved in epithelial-mesenchymal transition in oral cancer compared with other cancers.Cells Tissues Organs. 2007;185(1-3):40-7. doi: 10.1159/000101301. Cells Tissues Organs. 2007. PMID: 17587806 Review.
-
Mesenchymal to epithelial transition in development and disease.Cells Tissues Organs. 2007;185(1-3):7-19. doi: 10.1159/000101298. Cells Tissues Organs. 2007. PMID: 17587803 Review.
Cited by
-
Oroxylin A suppressed colorectal cancer metastasis by inhibiting the activation of the TGF-β/SMAD signal pathway.Sci Rep. 2024 Oct 15;14(1):24091. doi: 10.1038/s41598-024-75457-3. Sci Rep. 2024. PMID: 39406881 Free PMC article.
-
A comprehensive update on the potential of curcumin to enhance chemosensitivity in colorectal cancer.Pharmacol Rep. 2024 Sep 20. doi: 10.1007/s43440-024-00652-y. Online ahead of print. Pharmacol Rep. 2024. PMID: 39304638 Review.
-
The role of Rhizoma Paridis saponins on anti-cancer: The potential mechanism and molecular targets.Heliyon. 2024 Sep 2;10(17):e37323. doi: 10.1016/j.heliyon.2024.e37323. eCollection 2024 Sep 15. Heliyon. 2024. PMID: 39296108 Free PMC article. Review.
-
From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer.Front Immunol. 2024 Aug 23;15:1449525. doi: 10.3389/fimmu.2024.1449525. eCollection 2024. Front Immunol. 2024. PMID: 39247186 Free PMC article.
-
Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells.Acta Pharm Sin B. 2024 Aug;14(8):3457-3475. doi: 10.1016/j.apsb.2024.04.034. Epub 2024 May 8. Acta Pharm Sin B. 2024. PMID: 39220884 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
