Los Paranoicos follows the extravagant adventures of the very strange Luciano Gauna (daniel Hendler). A writer who lives forever reviewing his first screenplay, fearful of success, diseases of sexual transmission, women and especially, his goalkeeper. After sending his best friend to the hospital through a door slamming in the throat, then one of the children's animations that are his livelihood. Gauna must face his old friend Manuel (walter Jakob), the final member of that trio ever inseparable. When Manuel must travel, his girlfriend Sofia (Jazmin Stuart) must stay with Luciano in what is a real nightmare for our hermit hero. Unexpectedly develop a link that will endanger the relations of the group