[HTML][HTML] …�p55 accessory subunit of human DNA polymerase γ enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance
SE Lim, MJ Longley, WC Copeland�- Journal of Biological Chemistry, 1999 - ASBMB
… of the human DNA polymerase γ accessory subunit, the … of this accessory subunit on DNA
replication by DNA polymerase γ… accessory subunit as the cause of processive DNA synthesis …
replication by DNA polymerase γ… accessory subunit as the cause of processive DNA synthesis …
[PDF][PDF] …�p55 Accessory Subunit of Human DNA Polymerase Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance
SE Lim, MJ Longley, WC Copeland - researchgate.net
… for DNA—To investigate the cause of the high processivity conferred by the accessory
subunit we performed steady state kinetic analysis of the native HeLa pol …
subunit we performed steady state kinetic analysis of the native HeLa pol …
DNA polymerase gamma in mitochondrial DNA replication and repair
WC Copeland, MJ Longley�- The Scientific World Journal, 2003 - Wiley Online Library
… catalytic subunit of pol γ is sensitive to N-ethylmaleimide-… the p140•p55 complex display
nearly complete resistance to NEM … -kDa accessory subunit, which confers processivity to the pol …
nearly complete resistance to NEM … -kDa accessory subunit, which confers processivity to the pol …
[PDF][PDF] Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders
W Copeland, M Ponamarev, D Nguyen…�- Acta Biochimica�…, 2003 - bibliotekanauki.pl
… out exonucleolytic proofreading and its p55 accessory subunit. … a native heterodimer (Lim
et al., 1999). Reconstitution of p140�… processive DNA synthesis and confers N-ethylmaleimide …
et al., 1999). Reconstitution of p140�… processive DNA synthesis and confers N-ethylmaleimide …
Structural determinants in human DNA polymerase γ account for mitochondrial toxicity from nucleoside analogs
SE Lim, MV Ponamarev, MJ Longley…�- Journal of molecular�…, 2003 - Elsevier
… and overproduced the catalytic subunit of human pol γ in insect … , and the drug resistance
conferred by these mutations are … Cardiac mitochondrial DNA polymerase-gamma is inhibited …
conferred by these mutations are … Cardiac mitochondrial DNA polymerase-gamma is inhibited …
[HTML][HTML] Mutant POLG2 disrupts DNA polymerase γ subunits and causes progressive external ophthalmoplegia
… role of the p55 accessory subunit for highly processive mtDNA … DNA synthesis, and confers
N-ethylmaleimide resistance. … N-ethylmaleimide (NEM) protection assays, no enhancement of …
N-ethylmaleimide resistance. … N-ethylmaleimide (NEM) protection assays, no enhancement of …
[HTML][HTML] DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations
SSL Chan, WC Copeland�- Biochimica et Biophysica Acta (BBA)�…, 2009 - Elsevier
… poorly able to bind to the p55 accessory subunit, as shown by … suggesting that E1143G does
not confer a purely beneficial effect … of the catalytic subunit by N-ethylmaleimide. The G416A …
not confer a purely beneficial effect … of the catalytic subunit by N-ethylmaleimide. The G416A …
The mitochondrial DNA polymerase as a target of oxidative damage
MA Graziewicz, BJ Day, WC Copeland�- Nucleic acids research, 2002 - academic.oup.com
… subunit, the accessory subunit confers high processivity to … catalytic (p140) and accessory
(p55) subunits separately, as well … N ‐ethylmaleimide (NEM) inhibition of pol γ where the Hp55 …
(p55) subunits separately, as well … N ‐ethylmaleimide (NEM) inhibition of pol γ where the Hp55 …
The mitochondrial DNA polymerase in health and disease
WC Copeland�- Genome Stability and Human Diseases, 2010 - Springer
… DNA polymerase gamma has three main roles in health and … accessory subunit is a 55 kDa
protein (p55) required for tight DNA binding and processive DNA synthesis (Lim et al., 1999). …
protein (p55) required for tight DNA binding and processive DNA synthesis (Lim et al., 1999). …
Modulation of the W748S mutation in DNA polymerase γ by the E1143G polymorphismin mitochondrial disorders
SSL Chan, MJ Longley…�- Human molecular�…, 2006 - academic.oup.com
… the p55 accessory subunit is required for enhanced DNA … γ is extremely sensitive to inhibition
by N-ethylmaleimide (NEM… a 2-fold molar excess of p55 conferred resistance to NEM, most …
by N-ethylmaleimide (NEM… a 2-fold molar excess of p55 conferred resistance to NEM, most …