[PDF][PDF] Redox-Triggered Infection by

DS Human - Citeseer
DS Human
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MATERIALS AND METHODS MAbs, peptides, and sera. The following anti-gp120 MAbs
were used (each a whole immunoglobulin G [IgG], unless specified): CD4 binding site-
overlapping (CD4bs) MAb IgG1b12 and its monovalent fragment, Fab b12 (5); CD4-IgG2, a
chimera containing four copies of CD4 domains 1 and 2 fused to a IgG Fc domain (35);
2G12, against a unique gp120 epitope formed by terminal residues of N-linked glycans (41,
44); MAb 17b and Fab X5, directed to CD4-induced (CD4i) epitopes (33, 45); and 447-52D�…
MATERIALS AND METHODS
MAbs, peptides, and sera. The following anti-gp120 MAbs were used (each a whole immunoglobulin G [IgG], unless specified): CD4 binding site-overlapping (CD4bs) MAb IgG1b12 and its monovalent fragment, Fab b12 (5); CD4-IgG2, a chimera containing four copies of CD4 domains 1 and 2 fused to a IgG Fc domain (35); 2G12, against a unique gp120 epitope formed by terminal residues of N-linked glycans (41, 44); MAb 17b and Fab X5, directed to CD4-induced (CD4i) epitopes (33, 45); and 447-52D, against the V3 loop (9). MAbs against
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