Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene
HW Chang, RJ de Groot…�- Journal of General�…, 2010 - microbiologyresearch.org
Feline infectious peritonitis (FIP) is a lethal systemic disease caused by FIP virus (FIPV), a
virulent mutant of apathogenic feline enteric coronavirus (FECV). We analysed the 3c gene–
a proposed virulence marker–in 27 FECV-and 28 FIPV-infected cats. Our findings suggest
that functional 3c protein expression is crucial for FECV replication in the gut, but
dispensable for systemic FIPV replication. Whilst intact in all FECVs, the 3c gene was
mutated in the majority (71.4%) of FIPVs, but not in all, implying that mutation in 3c is not the�…
virulent mutant of apathogenic feline enteric coronavirus (FECV). We analysed the 3c gene–
a proposed virulence marker–in 27 FECV-and 28 FIPV-infected cats. Our findings suggest
that functional 3c protein expression is crucial for FECV replication in the gut, but
dispensable for systemic FIPV replication. Whilst intact in all FECVs, the 3c gene was
mutated in the majority (71.4%) of FIPVs, but not in all, implying that mutation in 3c is not the�…
Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene.
CHW Chang HuiWen, RJ Groot, HF Egberink… - 2010 - cabidigitallibrary.org
Feline infectious peritonitis (FIP) is a lethal systemic disease caused by FIP virus (FIPV), a
virulent mutant of apathogenic feline enteric coronavirus (FECV). We analysed the 3c gene-
a proposed virulence marker-in 27 FECV-and 28 FIPV-infected cats. Our findings suggest
that functional 3c protein expression is crucial for FECV replication in the gut, but
dispensable for systemic FIPV replication. Whilst intact in all FECVs, the 3c gene was
mutated in the majority (71.4%) of FIPVs, but not in all, implying that mutation in 3c is not the�…
virulent mutant of apathogenic feline enteric coronavirus (FECV). We analysed the 3c gene-
a proposed virulence marker-in 27 FECV-and 28 FIPV-infected cats. Our findings suggest
that functional 3c protein expression is crucial for FECV replication in the gut, but
dispensable for systemic FIPV replication. Whilst intact in all FECVs, the 3c gene was
mutated in the majority (71.4%) of FIPVs, but not in all, implying that mutation in 3c is not the�…
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