▪ Abstract ATP-sensitive K+ channels (KATP channels) play important roles in many cellular
functions by coupling cell metabolism to electrical activity. By cloning members of the novel�…

ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple�…

The oxidation of glucose represents a major source of metabolic energy for mammaliancells.
However, because the plasma membrane is impermeable to polar molecules such as�…

A member of the inwardly rectifying potassium channel family was cloned here. The
channel, called BIR (Kir6. 2), was expressed in large amounts in rat pancreatic islets and�…

Somatostatin is a tetradecapeptide that is widely distributed in the body. It acts on multiple
organs including brain, pituitary, gut, exocrine and endocrine pancreas, adrenals, thyroid�…

The human insulin receptor gene, INSR, and its promoter region have been isolated and
characterized. The gene spans greater than 120 kilobase pairs (kbp) and has 22 exons. All�…

Glucose-responsive (GR) neurons in the hypothalamus are thought to be critical in glucose
homeostasis, but it is not known how they function in this context. Kir6. 2 is the pore-forming�…

We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2.
Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6. 2 in COS1 cells�…

Two novel facilitative glucose transporter-like cDNAs have been isolated from human small
intestine and fetal skeletal muscle cDNA libraries by low stringency cross-hybridization with�…

Complementary DNA clones encoding a facilitative glucose transporter-like protein have
been isolated from human small intestine and muscle cDNA libraries. This 509-amino acid�…