The origins of the mesenchymal cells participating in tissue repair and pathological
processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly�…

Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell�…

Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development,
and this process is re-engaged in adults during wound healing, tissue regeneration, organ�…

Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption
of normal myocardial structures, results from excessive deposition of extracellular matrix�…

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells
found in complex tissues. This dynamic process helps organize the formation of the body�…

Humans circulate quadrillions of exosomes at all times. Exosomes are a class of
extracellular vesicles released by all cells, with a size range of 40–150 nm and a lipid�…

In recent years, the basement membrane (BM)—a specialized form of extracellular matrix
(ECM)—has been recognized as an important regulator of cell behaviour, rather than just a�…

BACKGROUND All cells, prokaryotes and eukaryotes, release extracellular vesicles (EVs)
as part of their normal physiology and during acquired abnormalities. EVs can be broadly�…

Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal
myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the�…

Cancer cells can divert metabolites into anabolic pathways to support their rapid
proliferation and to accumulate the cellular building blocks required for tumour growth�…