Edward Johnson Wayne: Difference between revisions

Sir Edward Johnson Wayne FRCP FRCPE (1902–1990) was an English physician, biochemist, thyroidologist, and professor of medicine.^[2]

Edward J. Wayne attended Leeds Central High School from 1914 to 1920 and then matriculated at the University of Leeds, graduating there in 1923 BSc in chemistry and in 1924 MSc after working on organic chemistry. He then went to the University of Manchester to do research^[2] under Hugh Stanley Raper^[3] on the intermediary metabolism of the fatty acids. Wayne graduated there in 1925 with a PhD.^[2]

He took classes in anatomy and physiology during a postdoctoral year of research at Manchester and then returned in 1926 to Leeds to study medicine, graduating MB, ChB in 1929.^[2] From 1930 to 1931 he was a demonstrator in physiology at the University of Leeds.^[1]

Wayne carried out some of the earliest trials on digoxin as well as an investigation on angina, using the ‘2-step test’ for the first time.^[2]

From 1931 to 1934 Wayne worked as an assistant under the cardiologist Thomas Lewis in the department of clinical research at University College Hospital, London. He qualified MRCP in 1932.^[2] From 1934 to 1953 he was Professor of Pharmacology and Therapeutics at the University of Sheffield,^[1] "establishing a reputation as a clinical scientist and as a talented director of research."^[4] He also became an associate physician to Sheffield Royal Infirmary. He was elected FRCP in 1937 and graduated MD in 1938. In 1953, as successor to Sir John William McNee, Wayne was appointed Regius Professor of the Practice of Medicine at Glasgow University. He held the professorship until his retirement as professor emeritus in 1967.^[2]

As Regius Professor at Glasgow he was able to use the facilities available in the Gardiner Institute at the Western Infirmary to pursue research into to thyroid disease, cardiovascular disease, osteoporosis and blood disorders.^[4]

... he was later appointed physician to the Children’s Hospital and to the Emergency Medical Service. In 1941 he took charge of the beds and consulting practice of Robert Platt, later Lord Platt ... during the latter's absence in military service. ... After the war he became once again a full-time professor of therapeutics ...^[2]

He was the Bradshaw Lecturer in 1953 and the Lumleian Lecturer in 1959. He was elected FRCPE in 1955. He was knighted in 1964.^[2]

Among many positions, Wayne was Chairman of the Clinical Research Board of the Medical Research Council, 1960 to 1964 and Honorary Physician to the Queen in Scotland, from 1954 to 1967. His work on the BMA's Committee on Alcohol and Road Accidents led to the introduction of the blood alcohol limit of 80 mg per 100 ml of blood in the Road Safety Act, 1967.^[4]

In 1932 in Scarborough, North Yorkshire he married Honora Nancy Halloran. Upon his death in 1990 he was survived by his widow, a son, and a daughter.^[1]

By using a statistical procedure partially based on discriminant analysis, James Crooks,^[5] I. P. C. Murray, and Edward J. Wayne developed a clinical diagnostic index (sometimes called the "Wayne score") in thyrotoxicosis. The procedure allocates a positive or negative score to each clinical feature and provides a numerical estimate of the degree of severity of the disease.^[6]

Older generations of endocrinologists were familiar with the use of Wayne's score and Billewicz's score^[7] for clinical diagnoses of hyperthyroidism and hypothyroidism, respectively. Contemporary medical textbooks have discarded those two diagnostic scores as old-fashioned. However, various scoring and grading systems in clinical thyroidology might still have value.^[8]

• "The estimation of hippuric and phenaceturic acids in urine". Biochem J. 22 (1): 183–187. 1928. PMC 1252104.
• "Painful Feet from the Physician's Point of View". Postgrad Med J. 19 (215): 239–242. October 1943. PMC 2478026.
• with J. F. Goodwin and H. B. Stoner: "The effect of adenosine triphosphate on the electrocardiogram of man and animals". Br Heart J. 11 (1): 55–67. January 1949. PMC 503617.
• with John L. Emery, L. M. Rose, and Sheila M. Stewart: "Procaine Penicillin with Aluminium Monostearate". Br Med J. 1 (4616): 1110–1112. 25 June 1949. PMC 2050391.
• with J. F. Goodwin and R. Steiner: "Transposition of the aorta and pulmonary artery demonstrated by angiocardiography". Br Heart J. 11 (3): 279–286. July 1949. PMC 479377.
• with J. Colquhoun and Joyce Burke"Procaine Penicillin with Aluminium Monostearate in Adults". Br Med J. 2 (4640): 1319–1322. 10 December 1949. PMC 2052081.
• with Alastair G. Macgregor: "Fluorescein test of circulation time in peripheral vascular disease". Br Heart J. 13 (1): 80–88. January 1951. PMC 503677.
• with G. W. Blomfield, A. G. Macgregor, and H. Miller: "Treatment of Thyrotoxicosis with Radioactive Iodine". Br Med J. 2 (4728): 373–381. 18 August 1951. PMC 2069753.
• "Medical Relief of Pain". Br Med J. 2 (4734): 787–789. 29 September 1951. PMC 2069831.
• "Correct Dose of Digitalin". Br Med J. 2 (4735): 850. 6 October 1951. PMC 2070026.
• with E. K. Blackburn, Joyce Burke, and Cissie Roseman: "Comparison of Liver Extract and Vitamin B12 in Maintenance Treatment of Pernicious Anaemia". Br Med J. 2 (4778): 245–248. 2 August 1952. PMC 2020972.
• "The Diagnosis of Thyrotoxicosis". Br Med J. 1 (4859): 411–419. 20 February 1954. PMC 2084526. (Bradshaw Lecture)
• "Treatment of Peripheral Vascular Disease in Old Age". Br Med J. 2 (4890): 718–720. 25 September 1954. PMC 2079051.
• "Peripheral circulation". Br Med J. 1 (4906): 151–152. 15 January 1955. PMC 2061045.
• "Atherosclerosis". Br Med J. 2 (4956): 1605–1606. 31 December 1955. PMC 1981747.
• with G. W. Blomfield, J. C. Jones, A. G. Macgregor, H. Miller, and R. S. Weetch: "Treatment of Thyrotoxicosis with Radioactive Iodine". Br Med J. 2 (4950): 1223–1229. 19 November 1955. PMC 1981295.
• with A. G. Macgregor: "Toxic Goitre". Br Med J. 2 (4956): 1618. 31 December 1955. PMC 1981754.
• with F. P. Muldowney and M. M. Bluhm: "Red-cell Survival in Paroxysmal Nocturnal Haemoglobinuria". Br Med J. 2 (5056): 1277–1279. 30 November 1957. PMC 1963168.
• with Russell Fraser and Selwyn Taylor: "Thyroid Association". Br Med J. 1 (5062): 103. 11 January 1958. PMC 2027101.
• with J. Crooks: "Potassium Perchlorate Sensitivity". Br Med J. 1 (5114): 112. 10 January 1959. PMC 1992184.
• "Clinical and Metabolic Studies in Thyroid Disease—I". Br Med J. 1 (5165): 1–11. 2 January 1960. PMC 1966357. (1st of 2 Lumleian Lectures)
• "Clinical and Metabolic Studies in Thyroid Disease—II". Br Med J. 1 (5166): 78–90. 9 January 1960. PMC 1966196. (2nd of 2 Lumleian Lectures)
• with James Crooks, W. Watson Buchanan, and E. MacDonald: "Effect of Pretreatment with Methylthiouracil on Results of 131I Therapy". Br Med J. 1 (5167): 151–154. 16 January 1960. PMC 1966292.
• with J. J. R. Duthie, R. H. Girdwood, Douglas Hubble, A. G. Macgregor, Andrew Wilson, and G. M. Wilson: ""Imferom" and Cancer". Br Med J. 2 (5193): 234. 16 July 1960. PMC 2097726.
• with W. Watson Buchanan, W. D. Alexander, J. Crooks, D. A. Koutras, J. R. Anderson, and R. B. Goudie: "Association of Thyrotoxicosis and Auto-immune Thyroiditis". Br Med J. 1 (5229): 843–847. 25 March 1961. PMC 1953621.
• with William D. Alexander, D. A. Koutras, J. Crooks, W. W. Buchanan, E. M. MacDonald, and M. H. Richmond: "Quantitative studies of iodine metabolism in thyroid disease". QJM: An International Journal of Medicine. 31 (3): 281–305. 1962.
• "Alcohol and Road Accidents". Br Med J. 2 (5370): 1467. 7 December 1963. PMC 1873518.

• with Demetrios A Koutras and William De Witt Alexander: Clinical aspects of iodine metabolism. Oxford: Blackwell Scientific Publications. 1964.