Pamaquine
Appearance
Pamaquine is an 8-aminoquinoline drug used for the treatment of malaria.
History
Pamaquine was the first synthetic antimalarial drug.
Adverse effects
Like primaquine, pamaquine causes haemolytic anaemia in patients with G6PD deficiency. Patients should therefore always be screened for G6PD deficiency prior to being prescribed pamaquine.
Uses
Pamaquine is effective against the hypnozoites of the relapsing malarias (P. vivax and P. ovale). One small clinical trial of pamaquine as a causal prophylactic was disappointing[1] (whereas primaquine is an extremely effective causal prophylactic).
Dosing
60mg once daily for 14–21 days.
When treating Plasmodium vivax, an initial course of chloroquine is unnecessary.
Synonyms
- Plasmaquine
References
- ^ Sweeney AW, Blackburn CRB, KH Rieckmann. (2004). "Short report: The activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains)". Am J Trop Med Hyg. 71 (2): 187–189.
{{cite journal}}
: CS1 maint: multiple names: authors list (link)