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Statements

Subject Item
dbr:4-ipomeanol
dbo:wikiPageWikiLink
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rdf:type
dbo:ChemicalCompound dbo:ChemicalSubstance n16:ChemicalObject wikidata:Q11173 owl:Thing
rdfs:label
4-Ipomeanol
rdfs:comment
4-Ipomeanol (4-IPO) is a pulmonary pre-toxin isolated from sweet potatoes infected with the fungus Fusarium solani. One of the 4-IPO metabolites is toxic to the lungs, liver and kidney in humans and animals. This metabolite can covalently bind to proteins, thereby interfering with normal cell processes.
foaf:name
4-Ipomeanol
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4
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dbc:3-Furyl_compounds dbc:Toxins dbc:Secondary_alcohols
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4
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4
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dbo:abstract
4-Ipomeanol (4-IPO) is a pulmonary pre-toxin isolated from sweet potatoes infected with the fungus Fusarium solani. One of the 4-IPO metabolites is toxic to the lungs, liver and kidney in humans and animals. This metabolite can covalently bind to proteins, thereby interfering with normal cell processes. The toxic metabolite, an enedial, is mostly formed in the bronchiolar exocrine cells (club cells) in the lungs of rodents. Necrosis of bronchiolar cells is therefore the primary damaging effect of the toxin, due to this location of metabolism. The secondary pathological effects are edema, congestion and hemorrhage caused by the destruction of the bronchiolar exocrine cells. In humans the metabolite is mostly formed in the liver, and causes liver toxicity.
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1-(Furan-3-yl)-4-hydroxypentan-1-one
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